Jeffries was able to record three Black National Championships, seven Mid-Eastern Athletic Conference (MEAC) championships, and a record of 179-132-6 in his 29-year career. He coached 19 years at his alma mater South Carolina State University (SCSU) in two stints, five years at Wichita State University, and five years at Howard University. Jeffries won almost 60 percent of the college games he coached, which made him the "winningest coach" in the 107-year history of SCSU and owner of more MEAC victories than any other coach. Jeffries was the first African American head coach of a NCAA Division I-A football program.