Humphrey was an All-American lineman at Tennessee State University under Coach John Merritt. Humphrey helped lead the Big Blue Tigers to a 35-3-1 record from 1965 to 1967. The 1967 team won the national championship for HBCU’s. Humphrey was drafted out of Tennessee State in the first round of the 1968 NFL Draft with the third overall choice by the Falcons. Humphrey was named to the Pro Bowl six times over the span of his career. He finished his career with 126½ career sacks with the Falcons and Eagles.